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Will Antidepressants Wreck Your Sex Life?

Seventy percent of people taking certain antidepressants complain of negative sexual side effects — but a new drug, and a few intimacy boosters, could help change that.

By Madeline R. Vann, MPH

Medically Reviewed by Pat F. Bass, III, MD, MPH

What sets Viibryd — an antidepressant approved by the FDA in January 2011 — apart from other depression medications on the market? Unlike most antidepressants, this one comes without any apparent sexual side effects.

Back in the 1950s, when antidepressants were first introduced to treat depression, physicians and patients didn’t talk much about sexual repercussions — this first generation of drugs had many unpleasant side effects. So when a new class of medications, selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac) and sertraline (Zoloft), came to the market, their fewer side effects were enthusiastically welcomed.

some antidepressants on the market now

some antidepressants on the market now

But it didn’t take long for patients to feel the brunt of SSRIs in the bedroom. Today, as many as 70 percent of patients taking certain antidepressants will say — if asked — that they have experienced changes in their sexual lives, from loss of sensation to lack of desire.

The sexual side effects of antidepressants may include

    Lowered libido
    Reduced genital sensitivity
    Delayed or absent orgasm (for both men and women)

The reasons for these sexual side effects are not fully understood. One theory is that SSRIs appear to interfere with nitric oxide, which plays a leading role in arousal and sexual response, resulting in lowered libido.

Experts acknowledge that it can be hard to tell whether sexual side effects come from medication or from the depression itself, which can also have an effect on sex drive. However, while depression may cause a lack of interest in sex, it typically does not cause physical difficulties with achieving orgasm or ejaculation.

5 Ways to Revive Your Sex Drive

There are several ways you can improve your sexual life while managing depression:

  1. Try other treatments. Treating depression is essential to your long-term quality of life. If you’re concerned about problems with antidepressants and sex, talk to your doctor about other treatment approaches, such as cognitive behavioral therapy.
  2. Lube up. For women, vaginal dryness can be a sexual side effect of antidepressants. A water-based vaginal lubricant may make sex more comfortable.
  3. Fool around. You may find that spending more time becoming aroused during foreplay helps overcome a delayed physical response.
  4. Talk it out. “We’ve found that people who communicate with their partners about their antidepressant side effects and who stay sexually active are less likely to let temporary problems become permanent,” says Tierney Lorenz, a researcher in the Sexual Psychophysiology Lab at the University of Austin in Texas.
  5. Get physical in other ways. Lorenz says she and her team are studying one potential cure for sexual side effects of antidepressants — exercise. “In the lab, we’ve found that exercising for 20 minutes before watching a sexual film doubled measures of sexual arousal in women taking antidepressants.” Consider working out as a couple — a romantic walk or an invigorating hike could put you in the mood.

Other Options for Antidepressants

If lifestyle approaches aren’t doing the trick, consider one of these medication-related strategies:

Ask your doctor about a different dosing schedule. “If you aren’t taking an extended-release tablet, you can try taking the meds at night just before sleep,” says Lorenz. “That way, the effect of the drug during the daytime will be lessened.”
Think about erectile dysfunction medications. Drugs known as PDE-5 inhibitors, such as sildenafil (Viagra), can be taken before you have intercourse and are effective in countering lowered libido. Although sildenafil is often thought of as a man’s medication, it has shown some promise in helping to improve women’s sexual response as well.
Rebalance changing levels of serotonin and dopamine. Your doctor may recommend daily doses of either buspirone (Buspar, Vanspar) or bupropion (Wellbutrin), both of which could counter the sexual side effects of SSRI antidepressants.
Switch antidepressants. People who take only bupropion to treat their depression are significantly less likely to report sexual side effects than people taking SSRI antidepressants. Another option is nefazodone (Serzone), although this medication appears to have a slightly higher risk of liver damage. In January of last year, the U.S. Food and Drug Administration approved the use of vilazodone (Viibryd) for depression treatment, which results in lowered libido in only about 4 percent of patients who take it.
Talk to your partner and your doctor to find the best option for you. And one word of caution: Don’t stop taking antidepressants on your own. Follow your doctor’s guidance for cutting back and ultimately stopping medication so that your depression can be resolved.

Last Updated: 5/14/2012

I read news from several health sites every day so I can share the best with you. I have been taking these medications for 25 years now and I can safely say that the side-effects are manageable and the medication has enhanced my life experience immeasurably. ~Sylvia

Will Antidepressants Wreck Your Sex Life?

don’t give up! 6 midlife sex myths

When it comes to sex after 40, one of the biggest misconceptions is that age will sour your sex life. But in reality, “many women in midlife say the quality of sex is better than ever because they know themselves and what pleases them,” says Barb DePree, MD, a gynecologist and director of women’s midlife services at Holland Hospital in Holland, Michigan. “Plus, they feel an intimacy and connection with their partner that’s unique to an older stage of life.”

Read on to discover six more sex myths doctors hear all the time — and the truth about how to have a satisfying sex life at any age or stage.

Go to Original

No, Cheaters Aren’t Looking for an Upgrade

From Esquire Magazine

?No, Cheaters Aren’t Looking for an Upgrade:anything new will do

A fun article about a wife’s nightmare.

Jessi Klein May 9, 2016

A year ago, I had one of those eerie, vivid nightmares that take place in the very room in which you are sleeping. I dreamed I was standing in the corner of my bedroom watching my husband have sex with Gisele in our bed. Not some random Gisele. Not Gisele Greenberg. Gisele the Supermodel. She was on top. It was a horrible dream.

I woke up angry and jealous. Even though the dream was over, I was in a visceral panic from watching my husband fuck someone so much hotter than me—in fairness, hotter than anyone. So I did the only rational thing a person could do in this situation, which was shake him awake. Sleepy and confused, he listened as I told him what he’d “done.”

“That’s ridiculous,” he said. “I would never do that to Tom Brady.”

Your partner is not “in the mood” as often as you

By Sylvia Wells, March 12, 2015

Laura Berman, PhD, is a leading sex and relationship educator and therapist, popular TV and radio host, New York Times best-selling author, and assistant clinical professor of ob-gyn and psychiatry at the Feinberg School of Medicine at Northwestern University in Chicago.

I receive messages from her frequently, and I approve of her sensitive and accurate advice. I don’t always agree with her, but that means I mostly agree with her.

Her advice is as relevant to the SexyAt60 crowd as it is to all the rest of us.

Here is a link to her article How can you encourage sexual energy in your relationship?

Dr. Laura Berman, PhD., Northwestern University

Dr. Laura Berman, PhD., Northwestern University


Q: My wife keeps telling me that women don’t want sex as often as men do. When we have sex, she enjoys it, yet she often says she is too tired or not in the mood. I love having sex with her, but at the end of the day, it seems like it’s the last thing on her mind. Do women really just not want sex as much as men do, or is there something I can do to help her be in the mood?

A: When it comes to libido, there are no rules for what is “normal.” Some women crave sex more than their partners, while other women find that their libido lags behind their partners’ desires. In fact, the issue of libidos (when one partner wants sex more than the other) is one of the most common that couples confront. The good news is that there are several things you can do to help inspire more sexual energy in your relationship, and as long as both you and your wife are on board, there is no reason why you can’t create the frequent and passionate sex you desire.

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